PRODUCT IDENTIFICATION
H.S. CODE
TOXICITY
CLASSIFICATION
PHYSICAL AND CHEMICAL PROPERTIES
AUTOIGNITION
NFPA RATINGS
REFRACTIVE INDEX
Stable under ordinary conditions. Light Sensitive.
GENERAL DESCRIPTION & EXTERNAL LINKS
Drug Information Portal (U.S. National Library of Medicine) - TRIMETHYLSULFOXONIUM IODIDE
http://www.simafex.com/
Trimethyl
Sulfoxonium Iodide (TMSOI)-A versatile reagent for the synthesis
of three membered-rings: Sulfoxonium ylides are a class of organic
compounds that have been extensively studied for their reacting
properties in modern synthesis. Several medicinal synthesis routes
have been investigated and patented by international pharmaceutical
companies, such as Schering, Merck & Co, Sumitomo pharmaceuticals,
Pfizer, or HMR. Dimethyl sulfoxonium methylide, known as the Corey-Chaykovsky
reagent (CCR), has proved to be a versatile nucleophilic agent capable
of reacting with different chemical systems. Undoubtedly, its industrial
availability coupled with its potential to achieve original chemical
transformations make it a choice reagent for the synthesis of new
leads and innovative substances.....
Local:
Trimethylsulfoxonium iodide
is useful for preparing ylides
in strong base condition. The Treatment with strong base
(such as sodium hydride) yields the ylide which adds to the carbonyl group of
ketones and aldehydes to generate the Corey-Chaykovsky reagent .
Also cyclopropanation can be carried out in ionic liquids with high yields preferentially to the double bond of alpha,beta-unsaturated esters to give
cyclopropyl esters.
Example of end products from Trimethylsulphoxonium iodide are anti-fungal agents such as Fluconazole.
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APPEARANCE
ASSAY
98.5% min
0.5% max
GHS
PICTOGRAMS
HAZARD STATEMENTS
H319:
Causes serious eye irritation
H315: Causes skin irritation
H335:
May cause respiratory irritation
H302: Harmful if
swallowed
PRECAUTIONARY STATEMENTS
P261:
Avoid breathing dust/fume/gas/mist/vapors/spray
P301+ P312:
IF SWALLOWED: Call a POISON CENTER or doctor/physician if
you feel unwell
P302+ P352: IF ON SKIN: Wash with plenty
of soap and water
P280: Wear protective gloves/protective
clothing/eye protection/face protection
P305 + P351 + P338: IF
IN EYES: Rinse cautiously with water for several minutes. Remove
contact lenses, if present and easy to do. Continue rinsing
Xn
Harmful
RISK PHRASES
22:
Harmful if swallowed.
36/37/38: Irritating to eyes,
respiratory system and skin.
SAFETY PHRASES
26:
In case of contact with eyes, rinse immediately with plenty
of water and seek medical advice.
37/39: Wear suitable
gloves and eye/face protection.